Clofazimine (lamprene) binds preferentially to GC-rich mycobacterial DNA, increases mycobacterial phospholipase A2 activity, and inhibits microbial K+ transport. It is weakly bactericidal against M. intracellulare. The drug also exerts an anti-inflammatory effect and prevents the development of erythema nodosum leprosum. Clofazimine is recommended as a component of multiple-drug therapy for leprosy. It also is useful for treatment of chronic skin ulcers produced by Mycobacterium ulcerans.

Clofazimine is orally absorbed and accumulates in tissues. Human leprosy from which dap-sone-resistant bacilli have been recovered has been treated with clofazimine with good results. However, unlike dapsone-sensitive microorganisms, in which killing occurs immediately after dapsone is administered, dapsone-resistant strains do not exhibit an appreciable effect until 50 days after initiation of therapy with clofazimine. The daily dose of clofazimine is usually 100 mg. Patients treated with clofazimine may develop red discoloration of the skin.

How To Deal With Rosacea and Eczema

How To Deal With Rosacea and Eczema

Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.

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