Common Adverse Effects

Diclofenac produces side effects (particularly Gi) in -20% of patients, and -2% of patients discontinue therapy as a result. Modest reversible elevation of hepatic transaminases in plasma occurs in 5-15% of patients. Transaminases should be measured during the first 8 weeks of therapy with diclofenac, and the drug should be discontinued if abnormal values persist or if other signs or symptoms develop. Other untoward responses to diclofenac include CNS effects, rashes, allergic reactions, fluid retention, and edema, and rarely impairment of renal function. The drug is not recommended for children, nursing mothers, or pregnant women. Consistent with its preference for COX-2, and unlike ibuprofen, diclofenac does not interfere with the antiplatelet effect of aspirin. Given these observations, diclofenac is not a suitable alternative to a selective COX-2 inhibitor in individuals at risk of cardiovascular or cerebrovascular disease.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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