DEA regulates each step of the handling of controlled substances from manufacture to dispensing. State agencies may impose additional regulations such as requiring that prescriptions for controlled substances be printed on triplicate or state-issued prescription pads or restricting the use of a particular class of drugs for specific indications. The most stringent law always takes precedence, whether it is federal, state, or local. Substances that come under the jurisdiction of the Federal Controlled
Substances Act (CSA) are divided into five schedules (Table A-1); individual states may have additional schedules. Criminal offenses and penalties for misuse generally depend on the schedule of a substance as well as the amount of drug in question.
Physicians must be authorized to prescribe controlled substances by the jurisdiction in which they are licensed and they must be registered with the DEA or exempted from registration as defined under the CSA. The number on the certificate of registration must be indicated on all prescription orders for controlled substances.
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