Coo H

Ampicillin^

Amoxicillin (ri = oh)

Carbenicillin

Carbenicillin indanyl (r1 = 5-indanol)

Ticarcillin

Good

Excellent

Extends spectrum of penicillin to include sensitive strains of Enterobacteriaceae*** Escherichia coli, Proteus mirabilis, Salmonella, Shigella, Haemophilus influenzae,*** and Helicobacter pylori.

Superior to penicillin for treatment of Listeria monocytogenes and sensitive enterococci. Amoxicillin most active of all oral ^-lactams against penicillin-resistant Streptococcus pneumoniae

Poor (not given orally)

Good No

Less active than ampicillin against Streptococcus species, Enterococcus faecalis, Klebsiella, and Listeria monocytogenes. Activity against Pseudomonas aeruginosa is inferior to that of mezlocillin and piperacillin

Poor (not given orally)

Mezlocillin

Poor (not given orally)

Chemical Structures and Major Properties of Various Penicillins (Continued)

R—C—NH2_CH—CH C^ Penicillins are substituted 6-aminopenicillanic acids

Major Properties

Nonproprietary Absorption after Oral Resistance to

Name Administration Penicillinase Useful Antimicrobial Spectrum

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