Cycloserine

Cycloserine (seromycin) is a broad-spectrum antibiotic that is used with other drugs in the treatment of tuberculosis when primary agents have failed. Cycloserine is d-4-amino-3-isoxazolidone.

antibacterial activity

Cycloserine inhibits M. tuberculosis in concentrations of 5—20 mg/mL in vitro. There is no cross-resistance between cycloserine and other tuberculostatic agents.

mechanism of action

Cycloserine and d-Ala are structural analogs; thus, cycloserine inhibits reactions in which d-Ala is involved in bacterial cell-wall synthesis.

absorption, distribution, and excretion

When given orally, 70—90% of cycloserine is rapidly absorbed. Cycloserine is distributed throughout body fluids and tissues. CSF concentrations are comparable to those in plasma. About 50% of a parenteral dose of cycloserine is excreted unchanged in the urine in the first 12 hours; a total of 65% is recoverable in the active form over a period of 72 hours. Very little of the antibiotic is metabolized. The drug may reach toxic concentrations in patients with renal insufficiency; it is removed from the circulation by hemodialysis.

therapeutic uses

Cycloserine is used only when retreatment is necessary or microorganisms are resistant to other drugs. It must be given together with other effective agents. The usual dose for adults is 250—500 mg twice daily.

untoward effects

Side effects typically affect the CNS, appearing within 2 weeks of therapy and disappearing after drug withdrawal. They include: somnolence, headache, tremor, dysarthria, vertigo, confusion, nervousness, irritability, psychotic states, paranoid reactions, catatonic reactions, twitching, ankle clonus, hyperreflexia, visual disturbances, paresis, and seizures. Large doses or concomitant ingestion of alcohol increases the risk of seizures. Cycloserine is contraindicated in individuals with a history of epilepsy and should be used with caution in individuals with a history of depression.

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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