The pharmacological effects of dobutamine (see Table 10-1 for structure) result from direct interactions with a and b receptors and are complex. The preparation of dobutamine used clinically is a racemate. The (-) isomer of dobutamine is a potent a1 agonist and pressor; (+) dobutamine is a potent a1 antagonist that can block the effects of (-) dobutamine. Both isomers are full agonists at b receptors, but the (+) isomer is more potent than the (-) isomer by -tenfold.

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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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