The pharmacological effects of dobutamine (see Table 10-1 for structure) result from direct interactions with a and b receptors and are complex. The preparation of dobutamine used clinically is a racemate. The (-) isomer of dobutamine is a potent a1 agonist and pressor; (+) dobutamine is a potent a1 antagonist that can block the effects of (-) dobutamine. Both isomers are full agonists at b receptors, but the (+) isomer is more potent than the (-) isomer by -tenfold.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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