Drug Interactions

Interactions between phenobarbital and other drugs usually involve induction of the hepatic CYPs by phenobarbital (see Table 19-2). Concentrations of phenobarbital in plasma may be elevated by up to 40% during concurrent administration of valproic acid (see below).

THERAPEUTIC USES Phenobarbital is an effective drug for generalized tonic-clonic and partial seizures. It is efficacious, inexpensive, and has low toxicity. However, its sedative effects and its tendency to disturb behavior in children have reduced its use.

Mephobarbital (mebaral) is N-methylphenobarbital. It is N-demethylated in the liver, and most of its activity during long-term therapy results from the accumulation of phenobarbital. Consequently, the pharmacological properties, toxicity, and clinical uses of mephobarbital are the same as those for phenobarbital.


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Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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