Drug Interactions

Interactions between phenobarbital and other drugs usually involve induction of the hepatic CYPs by phenobarbital (see Table 19-2). Concentrations of phenobarbital in plasma may be elevated by up to 40% during concurrent administration of valproic acid (see below).

THERAPEUTIC USES Phenobarbital is an effective drug for generalized tonic-clonic and partial seizures. It is efficacious, inexpensive, and has low toxicity. However, its sedative effects and its tendency to disturb behavior in children have reduced its use.

Mephobarbital (mebaral) is N-methylphenobarbital. It is N-demethylated in the liver, and most of its activity during long-term therapy results from the accumulation of phenobarbital. Consequently, the pharmacological properties, toxicity, and clinical uses of mephobarbital are the same as those for phenobarbital.

IMINOSTILBENES Carbamazepine

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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