UPTAKE Transporter-mediated hepatic uptake can cause drug-drug interactions among drugs that are actively taken up into the liver and metabolized and/or excreted in the bile. When an inhibitor of drug-metabolizing enzymes is highly concentrated in hepatocytes by active transport,
extensive inhibition of the drug-metabolizing enzymes may be observed because of the high concentration of the inhibitor in the vicinity of the drug-metabolizing enzymes.
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