Drugdrug Interactions Involving Transportermediated Hepatic

UPTAKE Transporter-mediated hepatic uptake can cause drug-drug interactions among drugs that are actively taken up into the liver and metabolized and/or excreted in the bile. When an inhibitor of drug-metabolizing enzymes is highly concentrated in hepatocytes by active transport,

FIGURE 2-6 Transporters in the hepatocyte that function in the uptake and efflux of drugs across the sinusoidal membrane and efflux of drugs into the bile across the canalicular membrane. See text for details of the transporters pictured.

extensive inhibition of the drug-metabolizing enzymes may be observed because of the high concentration of the inhibitor in the vicinity of the drug-metabolizing enzymes.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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