Nucleoside and Nucleotide Reverse Transcriptase Inhibitors
The HIV-encoded, RNA-dependent DNA polymerase, also called reverse transcriptase, converts viral RNA into proviral DNA that then is incorporated into a host cell chromosome. Inhibitors of this enzyme are either nucleoside/nucleotide analogs or nonnucleoside inhibitors (Figure 50-2 and Table 50-2). Like all available antiretroviral drugs, nucleoside and nonnucleoside reverse tran-scriptase inhibitors prevent infection of susceptible cells but have no impact on cells that already
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