Econazole

Miconazole readily penetrates the stratum corneum and persists there for >4 days after application. Less than 1% is absorbed into the blood. systemic absorption from the vagina is <1.3%. Adverse effects from vaginal application include burning, itching, or irritation in ~7% of recipients, and infrequently, pelvic cramps (0.2%), headache, hives, or skin rash. Irritation, burning, and maceration are rare after cutaneous application. Miconazole is considered safe for use during pregnancy.

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