Effects Of Clinically Used Opioids

Morphine and most other clinically used opiates exert their effects through m opioid receptors and affect a wide range of physiological systems. They produce analgesia, affect mood and rewarding behavior (see Chapter 23), and alter respiratory, cardiovascular, GI, and neuroendocrine function. 5-Opioid receptor agonists also are potent analgesics in animals and some have proved useful in humans. Agonists selective for k receptors produce analgesia that is mediated primarily at spinal

Properties of the Cloned Opioid Receptors

Receptor Subtype

Selective Ligands

Nonselective Ligands

Putative

Agonists

Antagonists

Agonists

Antagonists

Endogenous Ligands

m

DAMGO Morphine Methadone

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

Get My Free Ebook


Post a comment