Effects Of Clinically Used Opioids

Morphine and most other clinically used opiates exert their effects through m opioid receptors and affect a wide range of physiological systems. They produce analgesia, affect mood and rewarding behavior (see Chapter 23), and alter respiratory, cardiovascular, GI, and neuroendocrine function. 5-Opioid receptor agonists also are potent analgesics in animals and some have proved useful in humans. Agonists selective for k receptors produce analgesia that is mediated primarily at spinal

Properties of the Cloned Opioid Receptors

Receptor Subtype

Selective Ligands

Nonselective Ligands

Putative

Agonists

Antagonists

Agonists

Antagonists

Endogenous Ligands

m

DAMGO Morphine Methadone

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