Effects On Cognitive Function

Several cognitive functions, including auditory processing and attention, spatial organization, verbal learning, semantic and verbal memory, and executive functions, are impaired in schizophrenia patients. Potent D ^antagonist neuroleptics have very limited beneficial effects on such functions. Some atypical antipsychotic agents with mixed DJ5-HT2A activity (including clozapine, quetiapine, olanzapine, and risperidone), as well as the D2 partial agonist aripiprazole, seem to improve cognitive functioning in psychotic patients. Nevertheless, significant long-term gains in social and occupational function during long-term treatment of chronically psychotic patients with these drugs are not well documented.

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