Eflornithine (a-difluoromethylornithine, DFMO, ornidyl) is an irreversible suicide inhibitor of ornithine decarboxylase, which catalyzes the rate-limiting step in the biosynthesis of polyamines. Polyamines are required for cell division and normal cell differentiation. In trypanosomes, spermidine also is required for the synthesis of trypanothione, a conjugate of spermidine and glu-tathione that replaces many functions of glutathione in the parasite. Eflornithine is used to treat trypanosomiasis caused by T. brucei gambiense. The drug usually is curative even for late CNS stages of infection resistant to arsenicals but is largely ineffective for East African trypanosomiasis. Its high cost, production shortages, and difficult treatment regimen have limited use. Eflornithine is no longer available for systemic use in the U.S. but is available for treatment of Gambian trypanosomiasis by special request. The structure of eflornithine is:

10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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