Enzymeinhibitor Complex

FIGURE 36-2 Proton pump inhibitors. A. Inhibitors of gastric H+,K+-ATPase (proton pump). B. Conversion of omeprazole to a sulfenamide in the acidic secretory canaliculi of the parietal cell. The sulfenamide interacts covalently with sulfhydryl groups in the proton pump, thereby irreversibly inhibiting its activity. The other three proton pump inhibitors undergo analogous conversions.

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10 Ways To Fight Off Cancer

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