Ganglionic Stimulating Drugs

Nicotine and several other compounds stimulate ganglionic nicotinic receptors (Figure 9-4). Nicotine

Nicotine is medically and socially significant because of its presence in tobacco, its toxicity, and its propensity to cause dependence in its users. The chronic effects of nicotine and the untoward effects of the chronic use of tobacco are considered in Chapter 23. Nicotine is one of the few natural liquid alkaloids. It is a colorless, volatile base (pKa = 8.5) that turns brown and acquires the odor of tobacco on exposure to air.

TETRAMETHYLAMMONIUM (TMA)

TETRAMETHYLAMMONIUM (TMA)

1,1 -DIMETHYL-4-PHENYLPIPERAZINIUM (DMPP) FIGURE 9-4 Ganglionic stimulants.

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