Genetic Variation In Membrane Transporters Implications For Clinical Drug Response

Inherited disorders of membrane transport have been identified (Tables 2-2 and 2-3), and polymorphisms in membrane transporters that play a role in drug response are yielding new insights in pharmacogenetics (see Chapter 4). The most widely studied drug transporter is P-glycoprotein (MDR1, ABCB1); the ABCB1 genotype is associated with responses to anticancer drugs, antiviral agents, immunosuppressants, antihistamines, cardiac glycosides, and anticonvulsants. ABCB1 SNPs also have been associated with tacrolimus and nortriptyline neurotoxicity and susceptibility for developing ulcerative colitis, renal cell carcinoma, and Parkinson's disease.

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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