Hemostasis Vascular Occlusion

FIGURE 11-3 Local influences of platelet 5-HT. Aggregation triggers the release of 5-HT stored in platelets. Local actions of 5-HT include feedback actions on platelets (shape change and accelerated aggregation) mediated by 5-HT2A receptors, stimulation of NO production mediated by 5-HT1-like receptors on vascular endothelium, and contraction of vascular smooth muscle mediated by 5-HT2A receptors. These influences act in concert with many other mediators (not shown) to promote thrombus formation and hemostasis. See Chapter 54 for details of adhesion and aggregation of platelets and factors contributing to thrombus formation and blood clotting.

on vagus nerve endings elicits the Bezold-Jarisch reflex, causing bradycardia and hypotension. The local response of arterial blood vessels to 5-HT also may be inhibitory, the result of stimulated NO and prostaglandin synthesis and blockade of NE release from sympathetic nerves. On the other hand, 5-HT amplifies the local constrictor actions of NE, Angll, and histamine, which reinforce the hemostatic response to 5-HT.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook

Post a comment