Somatodendritic Autoreceptors (5-HT1A)

Presynaptic Autoreceptors (5-HT1D)

FIGURE 11-2 Two classes of 5-HT autoreceptors with differential localizations. Somatodendritic 5-HT1A autoreceptors decrease raphe cell firing when activated by 5-HT released from axon collaterals of the same or adjacent neurons. The receptor subtype of the presynaptic autoreceptor on axon terminals in the human forebrain has different pharmacological properties and has been classified as 5-HT1D; this receptor modulates the release of 5-HT. Postsynaptic 5-HT1 receptors are also indicated.

5-HT1D Receptor

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