The sulfonamides are associated with a number of skin and mucous membrane manifestations attributed to sensitization to sulfonamide, including various rashes, erythema nodosum, erythema multiforme of the Stevens-Johnson type, Behcet's syndrome, exfoliative dermatitis, and photosen-sitivity. These hypersensitivity reactions usually occur after the first week of therapy but may appear earlier in previously sensitized individuals. Fever, malaise, and pruritus frequently are present simultaneously. The incidence of untoward dermal effects is ~2% with sulfisoxazole, although a higher frequency is seen in patients with AIDS. A syndrome similar to serum sickness may appear after several days of sulfonamide therapy. Drug fever occurs in ~3% of patients treated with sulfisoxazole.
Focal or diffuse necrosis of the liver owing to direct drug toxicity or sensitization occurs in <0.1% of patients and rarely may progress to fulminant hepatic failure and death. Hepatomegaly, jaundice, and laboratory evidence of hepatocellular dysfunction usually appear 3-5 days after sulfonamide administration is started.
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Rosacea and Eczema are two skin conditions that are fairly commonly found throughout the world. Each of them is characterized by different features, and can be both discomfiting as well as result in undesirable appearance features. In a nutshell, theyre problems that many would want to deal with.