Alkylating Agents

In 1942, Goodman, Gilman, and colleagues launched the modern era of cancer chemotherapy with clinical studies of several nitrogen mustards in patients with lymphoma. At present five major types of alkylating agents are used in the chemotherapy of neoplastic diseases: (1) the nitrogen mustards, (2) the ethyleneimines, (3) the alkyl sulfonates, (4) the nitrosoureas, and (5) the triazenes. The methylhydrazine and platinum complexes also are included here, even though they do not formally alkylate DNA and use a different means to form covalent adducts with DNA.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

Get My Free Ebook


Post a comment