Czw

- androstenediol

»-testosterone OH

progesterone -»-17a OH-progesterone--androstenedione

17a-hydroxylase 17,20 lyase

FIGURE 58-1 Pathway of synthesis of testosterone in the Leydig cells of the testes. Leydig cells express steroid 17a-hydroxylase (CYP17), which carries out sequential 17-hydroxylation and C17-20 lyase reactions in the biosynthetic pathway to produce androgens. Bold arrows indicate favored pathways.

»-testosterone OH

effects that occur via the androgen receptor Testosterone and dihy-drotestosterone act as androgens via the AR. The AR is a member of the nuclear receptor super-family that contains amino-terminal, DNA-binding, and ligand-binding domains. After testosterone and dihydrotestosterone bind to the ligand-binding domain, they cause a conformational change that allows the ligand-AR complex to translocate to the nucleus, bind via the DNA-binding domain to androgen response elements on certain responsive genes, and regulate their transcription. One i,

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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