Wty

131I (radioactive iodine), 991-992 Ibandronate, 1070/, 1073 Ibuprofen adverse effects, 452 versus aspirin, 433/ chemistry, 452 in children, 433/ dosage, 433/, 452 interactions, 451-452

with lithium, 315 pharmacokinetics, 433/, 452 pharmacological properties, 451 Ibutilide, for cardiac arrhythmias, 587/, 589, 593/, 598

IDAMYCIN (idarubicin), 888 Idarubicin, 888 Idoxuridine, 815/, 824-825 IDV. See Indinavir IFEX (ifosfamide), 862 IFNs. See Interferon(s) Ifosfamide dosage, 862

pharmacokinetics, 862-863 therapeutic uses, 854/, 862 toxicity, 860, 860/, 862 ILOTYCIN(erythromycin), 1100/ Imatinib mesylate mechanisms of action, 895 pharmacogenetics, 895 pharmacokinetics, 895 resistance to, 895 therapeutic uses, 855/, 895 toxicity, 895 IMDUR (isosorbide mononitrate),

468 Imidazoles antifungal activity, 799/, 801 topical uses, 808-810 Imipenem adverse effects, 749 antimicrobial activity, 748-749

chemistry, 748, 748/ pharmacokinetics, 749 therapeutic uses, 749, 785/ Imipenem-cilastatin, 749 Imipramine, 279/, 290/, 623 Imiquimod, 815/, 1088-1089 IMITREX (sumatriptan), 195 Immune globulin intravenous, 922/, 923, 1092 for passive immunization, 922 preparations, 922/ Rho(D), 922/, 923 Immune system eicosanoids and, 421 ethanol consumption and, 379 prostaglandins and, 421 responses, 909 Immunization, 921-923 Immunoglobulin E in asthma, 462 in penicillin sensitivity, 739 therapy targeting, 468^69, 469/ Immunostimulatory drugs, 920-921 Immunosuppressive drugs antibodies, 917-920 antiproliferative and antimetabolic,

914-916 calcineurin inhibitors, 911-914 classes, 909 FTY720, 917

glucocorticoids, 910-911, 1030 in organ transplantation biologic induction therapy, 910 for established rejection, 910 maintenance immunotherapy, 910

sites of action, 910/ tolerance and, 920 IMMURAN (azathioprine), 658 IMODIUM (loperamide), 643 IMODIUM A-D (loperamide), 643 IMOGAM RABIS-HT (rabies immune globulin), 922/ Impaired glucose tolerance, 1055. See also Diabetes mellitus Impetigo, topical antibiotics for, 1083 Impotence alprostadil for, 424 phosphodiesterase 5 inhibitors for, 531

thiazide diuretics and, 546 IMURAN (azathioprine), 915 Inamrinone, for heart failure, 563/, 575

Inclusion criteria, 72 IND (investigational new drug), 81 Indapamide, 491/ Indinavir (IDV)

for HIV infection, 839/, 849-850 interactions with cyclosporine, 913 with itraconazole, 803/ with nonnucleoside reverse transcriptase inhibitors, 850/

with other protease inhibitors, 851/

mechanisms of action, 849 Indiplon, 269

INDOCIN (indomethacin), 447 Indocyanine green, 1112 Indomethacin adverse effects, 431/, 447, 1111 versus aspirin, 431/ chemistry, 446/

Indomethacin (Cont.): dosage, 431t fetal effects, 438 interactions, 447

with P adrenergic receptor antagonists, 548 metabolism, 447 ophthalmic effects, 1111 pharmacokinetics, 431t, 447 pharmacological properties, 447 therapeutic uses, 447 vasopressin response and, 504 Indoramin, 174 Infants. See also Newborns antiseizure drugs in, 334 congenital syphilis in, penicillin G

for, 736 sulfonamides in, 720 INFED (iron dextran), 939 INFERGEN (interferon-a), 815t Infertility clomiphene for, 1004 GnRH antagonists for, 976 Infiltration anesthesia, 249 Inflammation in asthma, 462, 463/ eicosanoids and, 421 kinins in, 413-414 leukotrienes and, 421 mechanisms, 428 phases, 428

platelet-activating factor in,

426-427 prostaglandins and, 421, 428 thromboxanes and, 421 Inflammatory bowel disease, 653-660 antibiotics for, 659 clinical characteristics, 653 cyclosporine for, 654t glucocorticoids for, 654t, 657 immunosuppressive agents for,

654t, 658-659 infliximab for, 654t, 659 mercaptopurine/azathioprine for,

654t, 658 mesalamine-based therapy for,

653-657, 654t, 656/ methotrexate for, 654t pathogenesis, 653, 655/ in pregnancy, 660 salicylates for, 443 subtypes, 653

supportive therapy, 659-660 therapeutic approach, 653, 654t Infliximab adverse effects, 659, 919 contraindications, 659 for Crohn's disease, 659, 919 mechanisms of action, 919 for psoriasis, 1091 therapeutic uses, 919, 1091 Influenza amantadine for, 827 oseltamivir for, 828 ribavirin for, 836 rimantadine for, 827 zanamivir for, 829 Inhalational anesthetics. See also speci/ic agents cellular mechanisms, 223 chemistry, 230/ molecular actions, 225 pharmacokinetics, 224t, 232, 233/ potency measurement, 223

Inhalers, drug delivery with, 462-463,

464/ Inhibition, 30, 208 INNOHEP (tinzaparin), 953 Inositol triphosphate, 19 Insertions/deletions (indels), 57, 59/ Insomnia. See also Sleep categories, 275 conditioned, 276 in the elderly, 276-277 long-term, 276 management, 275 medical illness and, 276 prescribing guidelines, 277 psychiatric illness and, 276 INSPRA (eplerenone), 495/ Insulin, 1037-1050 action cascade, 1040 biosynthesis, 1037 cellular actions, 1039-1040, 1039/ chemistry, 1037

for diabetes mellitus, 1041-1050.

See also Insulin therapy distribution and degradation,

1038-1039 gene transcription and, 1040 glucose metabolism and, 1040 glucose transport and, 1040 hypoglycemic actions, 1041/ interactions, 1050

with thiazide diuretics, 489 physiologic effects, 1041-1042 secretion, regulation of, 1037-1038 signaling pathways, 1039/ 1040 therapeutic uses. See Insulin therapy tyrosine kinase and, 1040 Insulin aspart, 1043/, 1044, 1045/ Insulin detemir, 1043/, 1046 Insulin glargine, 1043/, 1045, 1045/ Insulin glulisine, 1043/, 1044 Insulin-like growth factor (IGF), 1037

Insulin lispro, 1043/, 1044, 1045/ Insulin receptor(s), 1039/, 1040 Insulin therapy, 1043-1050 adverse effects, 1048-1049 allergy and resistance, 1049 continuous subcutaneous infusion,

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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