ANTIPARASITIC AND ANTIMICROBIAL EFFECTS Metronidazole and related nitroimidazoles are active in vitro against a wide variety of anaerobic protozoal parasites and anaerobic bacteria. The drug also has potent amebicidal activity against E. histolytica.

Metronidazole has antibacterial activity against all anaerobic cocci and both anaerobic gramnegative bacilli, including Bacteroides spp., and anaerobic spore-forming gram-positive bacilli. Metronidazole is clinically effective in trichomoniasis, amebiasis, and giardiasis, and in a variety of infections caused by obligate anaerobic bacteria, including Bacteroides, Clostridium, and microaerophilic bacteria such as Helicobacter and Campylobacter spp.

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