Indoramin

Indoramin is a competitive a1 antagonist that also antagonizes agonist effects at H1 and 5-HT receptors. Via a1 antagonism, indoramin lowers blood pressure with minimal tachycardia and decreases the incidence of attacks of Raynaud's phenomenon. Indoramin has modest bioavailability (<30%, with considerable variability), with extensive first-pass metabolism and an elimination t122 ~5 hours; some metabolites may be biologically active. Adverse effects include sedation, dry mouth, and failure of ejaculation. Indoramin is an effective antihypertensive, but has complex pharmacokinetics and lacks a well-defined therapeutic niche. Indoramin is not available in the U.S.

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