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Endogenous and Synthetic Opioid Peptides

Selected Endogenous Opioid Peptides

[Leu5]enkephalin Tyr-Gly-Gly-Phe-Leu

[Met5]enkephalin Tyr-Gly-Gly-Phe-Met

Dynorphin A Tyr-Gly-Gly-Phe-Leu-Arg-Arg-IIe-Arg-Pro-Lys-Leu-Lys-Trp-

Asp-Asn-Gln

Dynorphin B Tyr-Gly-Gly-Phe-Leu-Arg-Arg-Gln-Phe-Lys-Val-Val-Thr a-Neoendorphin Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro-Lys b-Neoendorphin Tyr-Gly-Gly-Phe-Leu-Arg-Lys-Tyr-Pro b-Endorphin Tyr-Gly-Gly-Phe-Met-Thr-Ser-Glu-Lys-Ser-Gln-Thr-Pro-Leu-

Val-Thr-Leu-Phe-Lys-Asn-Ala-Ile-Ile-Lys-Asn-Ala-Tyr-Lys-Lys-Gly-Glu

Novel Endogenous Opioid-Related Peptides

Orphanin FQ/Nociceptin Phe-Gly-Gly-Phe-Thr-Gly-Ala-Arg-Lys-Ser-Ala-Arg-Lys-Leu-Ala-Asn-Gln

Selected Synthetic Opioid Peptides

DAMGO [D-Ala2,MePhe4,Gly(ol)5]enkephalin

DPDPE [D-Pen2,d-Pen5]enkephalin

DSLET [D-Ser2,Leu5]enkephalin-Thr6

DADL [D-Ala2,D-Leu5]enkephalin

CTOP D-Phe-Cys-Tyr-D-Trp-Orn-Thr-Pen-Thr-NH2

FK-33824 [D-Ala2,N-MePhe4,Met(O)5-ol]enkephalin

[D-Ala2]Deltorphin I Tyr-D-Ala-Phe-Asp-Val-Val-Gly-NH2

[D-Ala2,Glu4]Deltorphin II Tyr-D-Ala-Phe-Glu-Val-Val-Gly-NH22

Morphiceptin Tyr-Pro-Phe-Pro-NH2

PL-017 Tyr-Pro-MePhe-D-Pro-NH2

DALCE [D-Ala2,Leu5,Cys6]enkepha2lin

Proorphanin

Prodynorphin

Proenkephalin

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