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FIGURE 4-5 Simulated concentration-dependence curves showing the rate of metabolism of a hypothetical substrate by the common genetic form of an enzyme and two nonsynonymous varrnnts. Variant A exhibits an increased Km and likely reflects a change in the substrate binding site of the protein by the substituted amino acid. Variant B exhibits a change in the maximum rate of metabolism (Vmax) of the substrate. This may be due to reduced expression level of the enzyme or to a decrease in its catalytic efficiency. Altered Km and Vmax may also be coexpressed in a single variant (not shown).

nonsynonymous variants in the coding region need to be refined and tested as predictors of function of SNPs in noncoding regions.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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