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Pegvisomant, 972 Pelvic inflammatory disease, ofloxacin for, 726 Pemetrexed mechanisms of action, 869,

870-871 therapeutic uses, 854/, 873 toxicity, 873 Pemirolast, 1108 Pemoline, 166

Pemphigus foliaceus, mycophenolate mofetil for, 1088 Pemphigus vulgaris azathioprine for, 1087 cyclophosphamide for, 1087 glucocorticoids for, 1077 methotrexate for, 1086 mycophenolate mofetil for, 1088 Penbutolol, 175/, 183/, 185 Penciclovir, 815/

absorption, distribution, and excretion, 820-821 adverse effects, 821 chemistry, 820, 820/ for herpes simplex virus infections, 1085

mechanisms of action, 820 therapeutic uses, 821 Penicillamine absorption, distribution, and excretion, 1129 for arsenic poisoning, 1138 for lead poisoning, 1134 for mercury poisoning, 1137 therapeutic uses, 1129 toxicity, 1129-1130 Penicillin(s), 728-741 adverse effects, 739-741 aminopenicillins, 737-738 antipseudomonal, 738-739 chemistry, 728, 729/ 730-732/ desensitization to, 740 hypersensitivity to, 739-740 isoxazolyl, 737

mechanisms of action, 728, 733/ penicillinase-resistant, 737 pharmacological properties, 729-734, 730-732/ probenecid and excretion of, 461 prophylactic uses, 714/, 736-737 resistance to, 728-729 semisynthetic, 728 Penicillin-binding proteins, 728 Penicillin G absorption, 734 adverse effects, 740 antimicrobial activity, 734 chemistry, 730/ distribution, 734 excretion, 734-735 pharmacological properties, 729, 730/

prophylactic uses, 714/, 736-737 therapeutic uses, 735-736 Penicillin G benzathine, 734 Penicillin G procaine, 734 Penicillin V absorption, 734 antimicrobial activity, 734 chemistry, 730/ distribution, 734 excretion, 734

pharmacological properties, 729, 730/

Penicillium marne//ei infections amphotericin B for, 799 itraconazole for, 802 PENLAC NAIL LACQUER (ciclopirox), 810 Pentamidine absorption, fate, and excretion, 692 adverse effects, 591, 692-693 antiprotozoal effects, 691 chemistry, 691/ interactions with cidofovir, 819 with foscarnet, 822 with nucleoside reverse transcriptase inhibitors, 844 with sodium channel inhibitors, 493

for leishmaniasis, 683 mechanisms of action, 692 for Pneumocystis infection, 692 resistance to, 692 therapeutic uses, 692 for trypanosomiasis, 682, 692 PENTASA (sulfasalazine), 655 Pentazocine, 352/, 353, 362-363 Pentetic acid (DTPA), 1127, 1140 Pentobarbital, 271/

PENTOLAlR(cyclopentolate), 1104/ PENTOSTAM (sodium stibogluconate),

693 Pentostatin dosage, 881

mechanisms of action, 880-881 therapeutic uses, 854/, 881 toxicity, 881 PENTOTHAL (thiopental), 226 Pentoxifylline, for claudication, 543 PEPCID (famotidine), 624 Peptic ulcer disease antacids for, 627-628, 627/ bismuth compounds for, 628 carbenoxolone for, 628 Helicobac/er pylori infection and,

630-631, 631/ histamine H2 receptor antagonists for, 6231/

misoprostol for, 423-424, 626, 631/ muscarinic receptor antagonists for, 123

631-642 pathophysiology, 629-630 pharmacotherapy, 630, 631/ platelet-activating factor and, 426 proton pump inhibitors for, 631/ rebamipide for, 628 stress-related, 626, 632 sucralfate for, 626

Peptides histamine release by, 403 as neurotransmitters, 211/, 217 Peptidoglycan, 728, 733/ PEPTO-BISMOL (bismuth subsalicylate), 643

Pep/ococcus infection clindamycin for, 778 metronidazole for, 688 Pep/os/rep/ococcus infection, metronidazole for, 688 Perchlorate, 991 PERCOCET (oxycodone/

acetaminophen), 366 PERCODAN (oxycodone/aspirin), 366

Perfluoroethane, 1110/ Perfluoromethane, 1110/ Perfluoro-n-butane, 1110/ Perfluoropentane, 1110/ Perfluoropropane, 1110/ Perfluorpropane gas, 1109 Pergolide, 340/, 342, 973 PERGONAL (menotropin), 976 Perhexiline, 539 PERIACTIN (cyproheptadine), 200-201 Perindopril, 521-522, 554 Perioral tremor, antipsychotics and, 304/

Peripheral arterial disease coronary heart disease and, 542 pharmacotherapy, 542-543 Peripheral nervous system barbiturates and, 272 nicotine and, 144 Peritonitis, dialysis-related, aminoglycosides for, 756, 758

PERMAPEN (penicillin G benzathine), 734

PERMAX (pergolide), 342 Permethrin, 1085 PERMITIL (fluphenazine), 308/

Peroxisome proliferator activated receptor (PPAR), 55 activators. See Fibrates Perphenazine, 307/, 308/, 647/ PERSANTINE (dipyridamole),

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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