Info

Guinea pig ileum

m

Decrease contraction

No effect

Mouse vas deferens

s

Decrease contraction

No effect

The actions listed for antagonists are seen with the antagonist alone. All the correlations in this table are based on studies in rats and mice, which occasionally show species differences. Thus, any extensions of these associations to humans are tentative. Clinical studies do indicate that m receptors elicit analgesia spinally and supraspinally. Preliminary work with a synthetic opioid peptide, [d-Ala2,d-Leu5]enkephalin, suggests that intrathecal d agonists are analgesic in humans.

The actions listed for antagonists are seen with the antagonist alone. All the correlations in this table are based on studies in rats and mice, which occasionally show species differences. Thus, any extensions of these associations to humans are tentative. Clinical studies do indicate that m receptors elicit analgesia spinally and supraspinally. Preliminary work with a synthetic opioid peptide, [d-Ala2,d-Leu5]enkephalin, suggests that intrathecal d agonists are analgesic in humans.

Opioid Receptor Signaling and Consequent Intracellular Events

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