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Medications Commonly Used to Treat Inflammatory Bowel Disease

Crohn's Disease

Ulcerative Colitis

Active Disease

Maintenance

Active disease

Class/Drug

MildModerate

Moderate-Severe

Fistula

Medical Remission

Surgical Remission

Distal Colitis

MildModerate

Maintenance

Moderate-Severe

Mesalamine

Enema Oral

Antibiotics (metronidazole, ciprofloxacin, others) Corticosteroids, classic and novel Enema, foam, suppository Oral

Intravenous Immunomodulators 6-MP/AZA Methotrexate Cyclosporine Biological response modifiers Infliximab

"Distal colonic disease only. fcFor adjunctive therapy.

"Some data to support use; remains controversial. ^Selected patients.

ABBREVIATIONS: 6-MP, 6-mercaptopurine; AZA, azathioprine.

Lumen

Bacteria

Antibiotics Probiotics

Epithelium

Lamina propria

Anti-IL-12

Epithelium

Anti-IL-12 Anti-TNF-a

Endothelium

Blood vessel lumen

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