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*Average and range.

»May have multiphasic elimination with much longer terminal t1/2.

^Half-life of the main active metabolite (parent drug t1/2 ca. 3-4 hours).

^Estimated, assuming similarity to fluphenazine.

*Average and range.

»May have multiphasic elimination with much longer terminal t1/2.

^Half-life of the main active metabolite (parent drug t1/2 ca. 3-4 hours).

^Estimated, assuming similarity to fluphenazine.

Although cross-tolerance may occur among antipsychotic drugs, clinical problems occur in making rapid changes from high doses of one type of agent to another. Sedation, hypotension, and other autonomic effects or acute extrapyramidal reactions can result. Clinical worsening of psychotic symptoms is particularly likely after rapid discontinuation of clozapine and is difficult to control with alternative antipsychotics.

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