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*Average and range.

»May have multiphasic elimination with much longer terminal t1/2.

^Half-life of the main active metabolite (parent drug t1/2 ca. 3-4 hours).

^Estimated, assuming similarity to fluphenazine.

*Average and range.

»May have multiphasic elimination with much longer terminal t1/2.

^Half-life of the main active metabolite (parent drug t1/2 ca. 3-4 hours).

^Estimated, assuming similarity to fluphenazine.

Although cross-tolerance may occur among antipsychotic drugs, clinical problems occur in making rapid changes from high doses of one type of agent to another. Sedation, hypotension, and other autonomic effects or acute extrapyramidal reactions can result. Clinical worsening of psychotic symptoms is particularly likely after rapid discontinuation of clozapine and is difficult to control with alternative antipsychotics.

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Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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