Some Actions of 5-HT in the Gastrointestinal Tract




Enterochromaffin cells

Enteric ganglion cells (presynaptic)

Enteric ganglion cells (postsynaptic)

Smooth muscle, intestinal Smooth muscle, stomach fundus Smooth muscle, esophagus

Release of 5-HT Inhibition of 5-HT release Release of ACh Inhibition of ACh release Fast depolarization Slow depolarization Contraction Contraction Contraction

5-HT3 5-HT4 5-HT4

5-HTip, 5-htib




5-HT2B 5-HT4

ABBREVIATION: ACh, acetylcholine

ABBREVIATION: ACh, acetylcholine

Vascular Injury

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