Compounds affecting the H3 and H4 receptors exhibit some lack of specificity, although JNJ7777120 seems to be a relatively specific H4 antagonist. JNJ7777120 is 1-[(5-chloro-1H-indol-2-yl) carbonyl]-4-methylpiperazine.



ch2cooh ch2cooh of mast cells and basophils via high-affinity Fc receptors that are specific for IgE. This receptor, FceRI, consists of a, b, and two g chains. The IgE molecules function as receptors for antigens and, via FceRI, interact with signal-transduction systems in the membranes of sensitized cells (see Chapter 27).

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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