Compounds affecting the H3 and H4 receptors exhibit some lack of specificity, although JNJ7777120 seems to be a relatively specific H4 antagonist. JNJ7777120 is 1-[(5-chloro-1H-indol-2-yl) carbonyl]-4-methylpiperazine.



ch2cooh ch2cooh of mast cells and basophils via high-affinity Fc receptors that are specific for IgE. This receptor, FceRI, consists of a, b, and two g chains. The IgE molecules function as receptors for antigens and, via FceRI, interact with signal-transduction systems in the membranes of sensitized cells (see Chapter 27).

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