Info

Age >65 years

None

Clcr <30

Investigational.

^Systemic absorption 4—17% after inhalation.

*For antivirally active oseltamivir carboxylate (GS4071).

Investigational.

^Systemic absorption 4—17% after inhalation.

*For antivirally active oseltamivir carboxylate (GS4071).

concentrations in nasal mucus are 50% higher than those in plasma. Amantadine is excreted largely unmetabolized in the urine. Because amantadine's elimination is highly dependent on renal function, the elimination t1/2increases up to twofold in the elderly and even more with renal impairment. Dose adjustment is advised even with mildly decreased renal function. In contrast, rimantadine is metabolized extensively by hydroxylation, conjugation, and glucuronidation; 60—90% is excreted in urine as metabolites.

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