Integrative Chemical Communication In The Cns And Neuropharmacology

A central underlying concept of neuropsychopharmacology is that drugs that influence behavior and improve the functional status of patients with neurological or psychiatric diseases act by enhancing or blunting the effectiveness of specific combinations of synaptic transmitter actions.

Four research strategies provide the neuroscientific substrates of neuropsychological phenomena: molecular (or biochemical), cellular, multicellular (or systems), and behavioral. Molecular mechanisms include: (1) ion channels, which provide for changes in excitability induced by neurotransmitters; (2) neurotransmitter receptors; (3) auxiliary intramembranous and cytoplasmic transductive molecules that couple these receptors to intracellular effectors for short-term changes in excitability and for longer-term regulation through alterations in gene expression; and (4) transporters for the conservation of released transmitter molecules by reaccumulation into nerve terminals, and then into synaptic vesicles (see Chapter 6). Vesicular transporters are distinct from the plasma membrane proteins involved in transmitter uptake into nerve terminals. Electrical excitability of neurons occurs through modifications of the transmembrane ion channels that all neurons express in abundance. Discriminative ion channels (Figures 12—2 and Chapter 9) regulate the flow of the three major cations, Na+, K+ and Ca2+, and Cl- anions. Two other families of channels regulate ion fluxes: cyclic nucleotide-modulated channels, and transient receptor potential (TRP) channels.

Ion channels

A a1 subunits for Ca2+, Na+ channels w

Was this article helpful?

0 0
Anti Ageing And Skincare Made Easy

Anti Ageing And Skincare Made Easy

Not Too Happy With Your Dull, Lifeless Skin? Do You Get Self-Conscious About Your Looks Especially The Evening You Need To Attend A Party? Are You Frustrated With Your Futile Attempts To Get Back Your Once-Glowing Skin? Fret Not Finally Discover How You Can Bring In A Natural Glow To Your Skin And Uncover Super Effective Tips And Strategies To Enliven Your Looks Once Again Enjoy A Perfectly Healthy Skin That Breathes With HappinessAnd Make Every Head Turn To Take A Second Look At You

Get My Free Ebook

Post a comment