Interactions Between Drugs

Marked alterations in the effects of some drugs can result from coadministration with another agent. Such interactions can cause toxicity or inhibit the drug effect and the therapeutic benefit.

Drug interactions always should be considered when unexpected responses to drugs occur. Understanding the mechanisms of drug interaction provides a framework for preventing them. Drug interactions may be pharmacokinetic (i.e., the delivery of a drug to its site of action is altered by a second drug) or pharmacodynamic (i.e., the response of the drug target is modified by a second drug).

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