Itraconazole

ABSORPTION, DISTRIBUTION, AND EXCRETION Itraconazole (sporonox) is available as a capsule and solutions for oral or intravenous administration. The capsule is better absorbed with food, but the oral solution is better absorbed in the fasting state and provides peak plasma concentrations that are >150% of those obtained with the capsule. Both the oral solution and intravenous formulations are solubilized in a 40:1 weight ratio of itraconazole:hydroxypropyl-b-cyclodextrin. Itraconazole and its active metabolite hydroxy-itraconazole are >99% bound to plasma proteins and neither appears in urine or CSF. The t1/2 of itraconazole is ~30 hours; steady-state levels are not reached for 4 days (7 days for hydroxy-itraconazole); thus, loading doses are used when treating deep mycoses. Severe liver disease increases itraconazole plasma concentrations. Itraconazole should not be used for onychomycosis during pregnancy or in women contemplating pregnancy (category C).

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Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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