Therapy typically involves a calcineurin inhibitor (e.g., cyclosporine or tacrolimus), glucocorticoids, and mycophenolate mofetil (a purine metabolism inhibitor; see below), each directed at a discrete site in T-cell activation. Alternatively, sirolimus can be used to limit exposure to the nephrotoxic calcineurin inhibitors. Glucocorticoids, azathioprine, cyclosporine, tacrolimus, mycophenolate mofetil, sirolimus, and various monoclonal and polyclonal antibodies are all approved for use in transplantation.
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