Mdr2

Mouse

PPARa

Ciprofibrate (0.05% w/w in diet)

Effect of Ligand

T Transcription activity (promoter assay) T Expression in duodenum in healthy subjects ■!• Oral bioavailability of digoxin in healthy subjects

■!• AUC of talinolol after IV and oral administration in healthy subjects

T Expression in duodenum in healthy subjects

T Expression in human hepatocytes T Expression in HepG2 cells T Expression in mouse hepatocyte

T Expression in hepatocyte of PXR KO mice (promoter assay) T Expression in rat hepatocytes T Transcription activity (promoter assay) T Transcription activity (promoter assay) ■!• RAR mediated transcription Indirect effect on HNF1a expression T Expression in hepatoma cells T Expression in the liver

Families in the Human Solute Carrier Superfamily

Number Selected

Gene

Diabetes 2

Diabetes 2

Diabetes is a disease that affects the way your body uses food. Normally, your body converts sugars, starches and other foods into a form of sugar called glucose. Your body uses glucose for fuel. The cells receive the glucose through the bloodstream. They then use insulin a hormone made by the pancreas to absorb the glucose, convert it into energy, and either use it or store it for later use. Learn more...

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