Mechanism Of Action Of

Extracellular PAF exerts its actions by stimulating a specific GPCR that is expressed in numerous cell types. The PAF receptor's strict recognition requirements, including a specific head group and specific atypical sn-2 residue, also are met by oxPLs. The PAF receptor couples with Gg to activate the PLC-IP-Ca2+ pathway and phospholipases A2 and D such that AA is mobilized from diacylglycerol, resulting in the synthesis of PGs, TxA2, or LTs, which may function as extracellular mediators of the effects of PAF. PAF also may exert actions without leaving its cell of origin. For example, PAF is synthesized in a regulated fashion by endothelial cells stimulated by inflammatory mediators. This PAF is presented on the surface of the endothelium, where it activates the PAF receptor on juxtaposed cells, including platelets, polymorphonuclear leukocytes, and mono-cytes, and acts cooperatively with P-selectin to promote adhesion. Endothelial cells under oxidant stress release oxPLs, which activate leukocytes and platelets and can spread tissue damage.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment