Mechanism Of Action

The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many grampositive bacteria, topoisomerase IV is the primary target. For many gram-negative bacteria, DNA gyrase is the primary quinolone target, as illustrated in Figure 43-3. The quinolones inhibit gyrase-mediated DNA supercoiling at concentrations that correlate well with their effective antibacterial actions. Mutations of gyrA can confer resistance to these drugs. Topoisomerase IV separates catenated DNA molecules that result from DNA replication, and also is a target for quinolones.

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