Mechanism Of Action

The quinolone antibiotics target bacterial DNA gyrase and topoisomerase IV. For many grampositive bacteria, topoisomerase IV is the primary target. For many gram-negative bacteria, DNA gyrase is the primary quinolone target, as illustrated in Figure 43-3. The quinolones inhibit gyrase-mediated DNA supercoiling at concentrations that correlate well with their effective antibacterial actions. Mutations of gyrA can confer resistance to these drugs. Topoisomerase IV separates catenated DNA molecules that result from DNA replication, and also is a target for quinolones.

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10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

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