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Methamphetamine (desoxyn) acts centrally to release DA and other biogenic amines and to inhibit neuronal and vesicular monoamine transporters and MAO. Small doses have prominent central stimulant effects without significant peripheral actions; somewhat larger doses produce a sustained rise in systolic and diastolic blood pressures, due mainly to cardiac stimulation and an increase in cardiac output secondary to venoconstriction. Methamphetamine is a schedule II drug and is widely abused (see Chapter 23).

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