Midodrine (proamatine) is an orally effective a1 receptor agonist. It is a prodrug; its activity is due to its conversion to an active metabolite, desglymidodrine, which achieves peak concentrations ~1 hour after a dose of midodrine. The t/2 of desglymidodrine is ~3 hours; its duration of action is 4-6 hours. Midodrine stimulates contraction of both arterial and venous smooth muscle, and has useful effects in treating autonomic insufficiency and postural hypotension. A frequent complication in these patients is supine hypertension, which can be minimized by avoiding dosing prior to bedtime and by elevating the head of the bed. Typical dosing, achieved by careful titration of blood pressure responses, is 2.5-10 mg 3 times daily.

Blood Pressure Health

Blood Pressure Health

Your heart pumps blood throughout your body using a network of tubing called arteries and capillaries which return the blood back to your heart via your veins. Blood pressure is the force of the blood pushing against the walls of your arteries as your heart beats.Learn more...

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