Molecular Actions

There is strong evidence that ligand-gated ion channels are important targets for anesthetic action. Chloride channels gated by the inhibitory GABAa receptors (see Chapters 12 and 16) are sensitive

Table 13-1

Properties of Inhalational Anesthetic Agents

Anesthetic Agent


EC50» for Suppression of Memory (vol %)

Vapor Pressure (mm Hg at 20°C)

Partition Coefficient at 37°C Blood:Gas Brain:Blood Fat:Blood

Recovered as Metabolites (%)


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