NaNa

FIGURE 19-1 Antiseizure drug-enhanced Na+ channel inactivation. Some antiseizure drugs (shown in blue text) prolong the inactivation of the Na+ channels, thereby reducing the ability of neurons to fire at high frequencies. Note that the inactivated channel itself appears to remain open, but is blocked by the inactivation gate (I). A, activation gate.

FIGURE 19-1 Antiseizure drug-enhanced Na+ channel inactivation. Some antiseizure drugs (shown in blue text) prolong the inactivation of the Na+ channels, thereby reducing the ability of neurons to fire at high frequencies. Note that the inactivated channel itself appears to remain open, but is blocked by the inactivation gate (I). A, activation gate.

vigabatrin vigabatrin

valproate tiagabine

— GABA binding site

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