Nc

H2N^sy Nx

OC(CH3)2COOH

2 och3

*T, tablet; C, capsule; O, oral suspension; I, injection.

^Cefoxitin, a cephamycin, has a —OCH3 group at position 7 of cephem nucleus. ^Cefuroxime axctil is the acetyloxyethyl ester of cefuroxime.

^Loracarbef, a carbacephem, has a carbon instead of sulfur at position 1 of cephem nucleus. ^Cefpodoxime proxetil has a —COOCH(CH3)OCOOCH(CH3)2 group at position 4 of cephem nucleus.

C2H5

centa and are found in high concentrations in synovial and pericardial fluids. Penetration into the aqueous humor of the eye is relatively good after systemic administration of third-generation agents, but penetration into the vitreous humor is poor. Concentrations sufficient for therapy of ocular infections owing to gram-positive and certain gram-negative microorganisms likely can be achieved after systemic administration. Concentrations in bile usually are high, especially with cef-operazone and cefpiramide.

Specific Agents

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