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Nitazoxanide has been used as a single agent to treat mixed infections with intestinal parasites (protozoa and helminths). Effective parasite clearance after nitazoxanide treatment was shown for G. intestinalis, E. histolytica/E. dispar, B. hominis, C. parvum, C. cayetanensis, I. belli, H. nana, T. trichura, A. lumbricoides, and E. vermicularis, although more than one course of therapy was sometimes required. Nitazoxanide has been used to treat infections with G. intestinalis that are resistant to metronidazole and albendazole.

TOXICITY AND SIDE EFFECTS Adverse effects are rare with nitazoxanide. A greenish tint to the urine is seen in most individuals taking nitazoxanide. Nitazoxanide is a category B agent for use in pregnancy based on animal studies, but there is no clinical experience with its use in pregnant women or nursing mothers.

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