In general, smooth muscles respond to amphetamine as they do to other sympathomimetic amines. The contractile effect on the sphincter of the urinary bladder is particularly marked, and for this reason amphetamine has been used in treating enuresis and incontinence. Pain and difficulty in micturition occasionally occur. GI effects are unpredictable: relaxation if enteric activity is pronounced, stimulation if the gut already is relaxed. The response of the human uterus varies, but there usually is an increase in tone.
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