Manifestations of poisoning with b receptor antagonists depend on the pharmacological properties of the ingested drug. Hypotension, bradycardia, prolonged AV conduction times, and widened QRS complexes are common manifestations. Seizures and depression may occur. Hypoglycemia is rare, and bronchospasm is uncommon in the absence of pulmonary disease. Significant bradycardia should be treated with atropine, but a cardiac pacemaker often is required. Large doses of isoproterenol or an a receptor agonist may be necessary to treat hypotension.
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