Patientcentered Therapeutics

Interindividual differences in drug delivery to its site(s) of action can profoundly influence therapeutic effectiveness and adverse effects. Some of the determinants of interindividual variation are

Table 5-1

A Ranking of the Quality of Comparative Studies

Randomized, controlled trials Double blinded Single blinded Unblinded

Observational studies Prospective cohort study Prospective case-control study Retrospective cohort study Retrospective case control study

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