Penicillamine

The d-isomer of penicillamine, d-^b-dimethylcysteine, is used clinically, although the l-isomer also forms chelation complexes. Penicillamine is an effective chelator of copper, mercury, zinc, and lead and promotes the excretion of these metals in the urine.

ABSORPTION, DISTRIBUTION, AND EXCRETION

Penicillamine is well absorbed (40—70%) from the GI tract and therefore has a decided advantage over many other chelating agents. Food, antacids, and iron reduce its absorption. Peak concentrations in blood are obtained 1-3 hours after administration. Unlike cysteine, its nonmethylated parent compound, penicillamine, is somewhat resistant to attack by cysteine desulfhydrase or L-amino acid oxidase and is relatively stable in vivo. Hepatic biotransformation is responsible for most of the degradation of penicillamine, and very little is excreted unchanged. Metabolites are found in both urine and feces.

Was this article helpful?

0 0
10 Ways To Fight Off Cancer

10 Ways To Fight Off Cancer

Learning About 10 Ways Fight Off Cancer Can Have Amazing Benefits For Your Life The Best Tips On How To Keep This Killer At Bay Discovering that you or a loved one has cancer can be utterly terrifying. All the same, once you comprehend the causes of cancer and learn how to reverse those causes, you or your loved one may have more than a fighting chance of beating out cancer.

Get My Free Ebook


Post a comment